Lack of Methylation in the Upstream Region of Human Papillomavirus Type 6 from Aerodigestive Tract Papillomas

Summary, in English

Methylation of the high-risk human papillomavirus type 16 (HPV16) upstream regulatory region (URR) has been described, but whether methylation is present among low-risk HPVs is unknown. The methylation status of the HPV6 URR was analyzed in papillomas from the upper aerodigestive tract of six adult patients. All CpGs in the URR were unmethylated, from both basal/intermediate and superficial cells, suggesting that methylation is not involved in the regulation of transcription from the HPV6 URR, regardless of epithelial differentiation.

• Author: Agustin Ure; Ola Forslund
• Department/s: Clinical Microbiology, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2012
• Language: English
• Pages: 13790-13794
• Publication/Series: Journal of Virology
• Volume: 86
• Issue: 24
• Links: http://dx.doi.org/10.1128/JVI.01938-12
• Document type: Journal article
• Publisher: American Society for Microbiology
• Topic: Microbiology in the medical area
• Status: Published
• Research group: Clinical Microbiology, Malmö
• ISBN/ISSN/Other: ISSN: 1098-5514