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Limitations of chromosome classification by multicolor karyotyping

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Author

  • Charles Lee
  • David Gisselsson Nord
  • Charlotte Jin
  • Ann Nordgren
  • David O. Ferguson
  • Elisabeth Blennow
  • Jonathan A. Fletcher
  • Cynthia C. Morton

Summary, in English

Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schrock et al.1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful in prenatal, postnatal, and cancer cytogenetics. However, these technologies have inherent limitations that, in certain situations, may result in chromosomal misclassification. In this report, we present nine cases, which fall into five categories, in which multicolor karyotyping has produced erroneous interpretations. Most errors appear to have a similar mechanistic basis.

Publishing year

2001

Language

English

Pages

1043-1047

Publication/Series

American Journal of Human Genetics

Volume

68

Issue

4

Document type

Journal article

Publisher

Cell Press

Topic

  • Medical Genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 0002-9297