A tailored biocompatible neural interface for long term monitoring in neural networks
Author
Summary, in English
and cortex cerebri (papers I-III). In paper IV, we evaluated the importance of mechanical flexibility and demonstrated that probe flexibility has a significant impact on the astroglial scar, but not on the loss of neurons nearby. Moreover, by embedding the dummy probes in a gelatin matrix that dissolves shortly following implantation, neuronal cell death surrounding chronically (6 weeks) implanted electrodes was, for the first time, abolished. In paper V, sensory processing in primary somatosensory cortex during an episode of hyperalgesia was monitored using implanted neural interfaces in order to further evaluate the probe functionality and usefulness in neurophysiological research. By tracking the development of primary and secondary hyperalgesia as well as allodynia in the sensory cortex, we demonstrate the usefulness of our new neural interface and its capability to differentially and simultaneously record neural signals in different cortical laminae in awake freely moving animals.
Publishing year
2016
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2016:25
Full text
Document type
Dissertation
Publisher
Neuronano Research Center (NRC)
Topic
- Neurosciences
- Medical Biotechnology
Keywords
- Brain-machine interfaces
- neuroinflammation
- somatosensory cortex
- hyperalgesia
- allodynia
Status
Published
Research group
- Neuronano Research Center (NRC)
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-7619-248-1
Defence date
4 March 2016
Defence time
09:00
Defence place
Belfragesalen, Klinikgatan 32, BMC D15, Lund.
Opponent
- Thomas Stieglitz