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Mitochondrial ion circuits.

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Author

Summary, in English

Proton circuits across the inner mitochondrial membrane link the primary energy generators, namely the complexes of the electron transport chain, to multiple energy utilizing processes, including the ATP synthase, inherent proton leak pathways, metabolite transport and linked circuits of sodium and calcium. These mitochondrial circuits can be monitored in both isolated preparations and intact cells and, for the primary proton circuit techniques, exist to follow both the proton current and proton electrochemical potential components of the circuit in parallel experiments, providing a quantitative means of assessing mitochondrial function and, equally importantly, dysfunction.

Publishing year

2010

Language

English

Pages

25-35

Publication/Series

Essays in Biochemistry

Volume

47

Document type

Journal article

Publisher

Portland Press

Topic

  • Neurosciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 0071-1365