Apicidin Sensitizes Pancreatic Cancer Cells to Gemcitabine by Epigenetically Regulating MUC4 Expression.

Summary, in English

Mucin 4 (MUC4) has been linked to resistance to gemcitabine in pancreatic cancer cells. The aim of the present study was to assess whether epigenetic control of MUC4 expression can sensitize pancreatic cancer cells to gemcitabine treatment.

• Author: Daniel Ansari; Carlos Urey; Katarzyna Said Hilmersson; Monika Bauden; Fredrik Ek; Roger Olsson; Roland Andersson
• Department/s: Surgery (Lund); Chemical Biology and Therapeutics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2014
• Language: English
• Pages: 5269-5276
• Publication/Series: Anticancer research
• Volume: 34
• Issue: 10
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25275019?dopt=Abstract
• Document type: Journal article
• Publisher: International Institute of Cancer Research
• Topic: Cancer and Oncology
• Status: Published
• Research group: Chemical Biology and Therapeutics
• ISBN/ISSN/Other: ISSN: 1791-7530