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Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

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Author

Summary, in English

Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays; a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper glycosaminoglycan biosynthesis. We conclude that HSPGs play an important role in organizing the extracellular distribution of Wg.

Department/s

  • Invertebrate Developmental Biology, Stefan Baumgartner's group

Publishing year

2001

Language

English

Pages

87-94

Publication/Series

Development: For advances in developmental biology and stem cells

Volume

128

Issue

1

Document type

Journal article

Publisher

The Company of Biologists Ltd

Topic

  • Developmental Biology

Keywords

  • Drosophila melanogaster
  • Morphogen
  • HSPG
  • Wg signaling

Status

Published

Research group

  • Invertebrate Developmental Biology, Stefan Baumgartner's group

ISBN/ISSN/Other

  • ISSN: 1477-9129