The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Oral and faecal lactobacilli and their expression of mannose-specific adhesins in individuals with and without IgA deficiency

På svenska

Author

  • Elisabet Lonnermark
  • Forough Nowrouzinan
  • Ingegerd Adlerberth
  • Siv Ahrné
  • Agnes Wold
  • Vanda Friman

Summary, in English

Lactobacilli are present in the intestine and oral cavity of most adults. Secretory IgA in mucosal secretions may provide carbohydrate receptors for bacterial adhesins. Here, oral and faecal samples from 33 IgA-deficient individuals and 34 controls were cultured for lactobacilli, which were identified using species-specific PCR or partial 165 rDNA sequencing and tested for expression of mannose-specific adhesins. Lactobacilli were found in the oral cavity of 76% of IgA-deficient and 85% of control individuals. Lactobacillus paracasei and Lactobacillus gasseri dominated in both groups. Lactobacillus fermentum was less common in IgA-deficient individuals than in controls (p = 0.0055) and Lactobacillus salivarius was less common in symptomatic than in healthy IgA-deficient individuals (p = 0.0051). Faecal samples yielded lactobacilli in most individuals. L. paracasei was most frequent, followed by L. gasseri and Lactobacillus plantarum. Mannose-specific adhesins were expressed more frequently by oral than by faecal isolates (p = 0.032) and oral isolates adhered in higher numbers than faecal isolates (46 vs. 14 bacteria/cell, p = 0.0038). Faecal isolates from IgA-deficient individuals more frequently expressed mannose-specific adhesins than faecal isolates from controls (p = 0.039). Mannose-specific adhesins may be a colonisation factor in the oral cavity, and the presence of secretory IgA may modify adhesin expression. However, secretory IgA seems to have little influence on Lactobacillus species distribution. (C) 2011 Elsevier GmbH. All rights reserved.

Publishing year

2012

Language

English

Pages

53-60

Publication/Series

International Journal of Medical Microbiology

Volume

302

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Microbiology in the medical area

Keywords

  • Lactobacillus
  • IgA deficiency
  • Gut
  • Oral
  • Microbiota
  • Adhesion

Status

Published

ISBN/ISSN/Other

  • ISSN: 1618-0607