Action-based body maps in the spinal cord emerge from a transitory floating organization.
Author
Summary, in English
During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring, involving both sprouting and elimination of afferent connections, and provide evidence for cross-modality interactions in the alignment of the multisensory input. Thus, far from being inborn and stereotypic, the dorsal horn of the spinal cord now appears to be a highly adaptive brain-body interface.
Department/s
Publishing year
2008
Language
English
Pages
5494-5503
Publication/Series
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume
28
Issue
21
Links
Document type
Journal article
Publisher
Society for Neuroscience
Topic
- Neurosciences
Status
Published
Research group
- Neurophysiology
- Neuronano Research Center (NRC)
ISBN/ISSN/Other
- ISSN: 1529-2401