Low molecular mass proteins as markers for renal function and dialysis efficiency
Author
Summary, in English
Cystatin C has been proposed to be a marker of inflammation. In our study of patients, without any prior inflammation, who undergo elective surgery, the concentration of cystatin C was unaltered while an increase in the concentration of CRP was seen. This result shows that cystatin C is not a marker of inflammation.
Three different types of dialysis treatments (haemodialysis, haemofiltration, haemodiafiltration) were tested for their capacity to remove low molecular mass proteins (LMMP) and thus their potential for treatment of patients with kidney failure. The LMMP have been proposed to be uraemic toxins and must therefore be removed from the circulation. The result from our study showed that cystatin C, β2-microglobulin and β-trace protein can be used as markers for the efficiency of haemofiltration (HF) and haemodiafiltration (HDF). The elimination pattern of β-trace protein differs between HDF and HF and the free proteins might therefore be useful markers in the evaluation of different convective therapies.
Department/s
Publishing year
2013
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2013:79
Full text
Document type
Dissertation
Publisher
Division of Clinical Chemistry and Pharmacology, Faculty of Medicine, Lund University
Topic
- Medicinal Chemistry
- Pharmacology and Toxicology
Status
Published
Supervisor
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-87449-51-2
Defence date
13 September 2013
Defence time
09:00
Defence place
Segerfalkssalen, BMC, Sölvegatan 17, Lund
Opponent
- Elvar Theodorsson (professor)