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Regulation of kinin B(2) receptors by bradykinin in human lung cells.

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Author

  • Sara Bengtson
  • Jane Eddleston
  • Matthias Mörgelin
  • Bruce L Zuraw
  • Heiko Herwald

Summary, in English

Abstract Bradykinin is a potent mediator of inflammation that has been shown to participate in allergic airway inflammation. The biologic effects of bradykinin are mediated by binding and activating its cognate receptor, the B(2) receptor (B(2)R). In the lung fibroblast cell line IMR-90, binding of bradykinin to the B(2)R triggers down-regulation of the receptor surface expression, suggesting that bradykinin-induced inflammation is transient and self-limited. Notably, subjects with chronic airway inflammation continue to respond to BK following a first challenge. B(2)Rs are expressed on many different lung cell types, including airway epithelial cells. We therefore compared IMR-90 cells with the human lung epithelial cell line BEAS2B and found that B2R expression in the two cell types is differently regulated by BK. While BK induces a down-regulation of B(2)R in IMR-90 cells, the same treatment leads to an up-regulation of the receptor in BEAS2B cells. These results provide a possible explanation for the potency of bradykinin in inducing ongoing airway inflammation.

Publishing year

2008

Language

English

Pages

1435-1440

Publication/Series

Biological Chemistry

Volume

389

Document type

Journal article

Publisher

De Gruyter

Topic

  • Infectious Medicine

Status

Published

ISBN/ISSN/Other

  • ISSN: 1437-4315