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Binding studies on substrate- and enantio-selective molecularly imprinted polymers

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Author

Summary, in English

A molecularly imprinted polymer was prepared using tert-butyloxycarbonyl-L-phenylalanine as the print molecule and methacrylic acid as the functional monomer. The bulk polymer obtained was ground, sieved, packed into a column and investigated in the HPLC-mode by frontal chromatography to determine the number of binding sites and dissociation constants for the enantiomers interacting with the polymer. The dissociation constant for the L-enantiomer of the print molecule was lower than for the D-enantiomer (6.3 mM and 8.1 mM, respectively). This means that the affinity for the L-enantiomer was higher than for the D-enantiomer. The number of binding sites in the polymer giving rise to these dissociation constants were determined to be 28 μmol per g dry polymer.

Publishing year

1991

Language

English

Pages

1137-1145

Publication/Series

Analytical Letters

Volume

24

Issue

7

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Biochemistry and Molecular Biology

Status

Published

Research group

  • Nanomedicine and Biomaterials

ISBN/ISSN/Other

  • ISSN: 0003-2719