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Association between plasma homocysteine levels and mortality in elderly patients with mental illness.

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Author

Summary, in English

BACKGROUND/METHOD: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness. Plasma tHcy is known to be associated with cardiovascular disease, renal impairment and negative lifestyle factors, and has been shown to predict mortality in human subjects. Epidemiological data on this topic in elderly patients with mental illness are missing. We therefore investigated the association between plasma tHcy levels and mortality in these patients. RESULTS: The group of deceased patients showed higher age, higher plasma tHcy, lower renal function and lower serum folate than patients who were still alive. Only age, plasma tHcy and the presence of vascular disease significantly influenced mortality. CONCLUSION: The association between plasma tHcy level and mortality risk was probably explained in part by the two plasma tHcy determinants age and presence of vascular disease. The determination of plasma tHcy in elderly patients with mental illness may help to identify patients in need of more intensive treatment.

Publishing year

2009

Language

English

Pages

579-583

Publication/Series

Dementia and Geriatric Cognitive Disorders

Volume

27

Issue

6

Document type

Journal article

Publisher

Karger

Topic

  • Pharmacology and Toxicology
  • Psychiatry
  • Medicinal Chemistry
  • Geriatrics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1420-8008