Is Increased Thrombin Activation in Patients With Abdominal Aortic Aneurysms Dependent on Area or Volume of Aneurysm Thrombus Mass?

Summary, in English

Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10 patients with AAA having no or very little thrombus mass. Conclusion: Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA.

• Author: Tilo Kölbel; Tobias Donath; Karin Strandberg; Despina Flondell-Sité; Tobias Kuhme; Anders Gottsäter; Bengt Lindblad
• Department/s: Vascular Diseases - Clinical Research; Clinical Chemistry, Malmö
• Publishing year: 2010
• Language: English
• Pages: 113-118
• Publication/Series: Angiology
• Volume: 61
• Issue: 1
• Links: http://dx.doi.org/10.1177/0003319709335906
• Document type: Journal article
• Publisher: SAGE Publications
• Topic: Medicinal Chemistry; Cardiac and Cardiovascular Systems
• Keywords: Abdominal aortic aneurysm; Aneurysm thrombus; Coagulation activation; Thrombin activation
• Status: Published
• Research group: Vascular Diseases - Clinical Research; Clinical Chemistry, Malmö
• ISBN/ISSN/Other: ISSN: 0003-3197