Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

Summary, in English

Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.

• Author: P Piccini; D J Brooks; Anders Björklund; R N Gunn; P M Grasby; O Rimoldi; Patrik Brundin; Peter Hagell; Stig Rehncrona; Håkan Widner; Olle Lindvall
• Department/s: Neurobiology; Department of Experimental Medical Science; Older people's health and Person-Centred care; Neurosurgery; Neurology, Lund
• Publishing year: 1999
• Language: English
• Pages: 1137-1140
• Publication/Series: Nature Neuroscience
• Volume: 2
• Issue: 12
• Links: http://dx.doi.org/10.1038/16060
• Document type: Journal article
• Publisher: Nature Publishing Group
• Topic: Neurosciences
• Status: Published
• Research group: Neurobiology; Older people's health and Person-Centred care
• ISBN/ISSN/Other: ISSN: 1546-1726