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Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children

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Author

  • D Roberton
  • H Marshall
  • T M Nolan
  • E Sokal
  • J Diez-Domingo
  • Carl-Erik Flodmark
  • L Rombo
  • G Lewald
  • L Flor Jde
  • J M Casanovas
  • J Verdaguer
  • J Mares
  • D V Esso
  • I Dieussaert
  • M Stoffel
Show all

Summary, in English

This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7).

Publishing year

2005

Language

English

Pages

5099-5105

Publication/Series

Vaccine

Volume

23

Issue

43

Document type

Journal article

Publisher

Elsevier

Topic

  • Pediatrics

Keywords

  • Hepatitis A and B
  • Combined vaccine
  • Children

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-2518