Nanowires and Neural interfaces. Biocompatibility in the brain
Author
Summary, in English
A neural interface with a nanostructured surface needs to be protected from damage during the implantation procedure. In paper III, we showed that embedding the nanowire substrate in a temporary protective and stiffening matrix, consisting of gelatin and glycerol, preserved the majority of the nanowires during implantation into agar.
In paper IV, we showed that implanting multiple wire bundles in the brain does not result in an increased glial response to each individual implant. This implies that it is feasible to interface and interact with several brain structures in parallel without the confounding factor of an over all cumulatively increased glial response.
In summary, this thesis has provided key knowledge about how to design and implant a nanowire structured neural interface. The development of a seamlessly integrating neural interface would have immense implications in neuroscience research as well as in clinical settings.
Publishing year
2016
Language
English
Publication/Series
Doctoral dissertation series / Lund University, Faculty of Medicine.
Full text
- Available as PDF - 67 MB
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Document type
Dissertation
Publisher
Lund University: Faculty of Medicine
Topic
- Medical and Health Sciences
Keywords
- neural interface
- neurons
- BMI
- nanowires
- tissue responses
- rat
- biocompatibility
- astrocytes
- microglia
Status
Published
Research group
- Neuronano Research Center (NRC)
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-7619-319-8
Defence date
30 September 2016
Defence time
13:00
Defence place
Segerfalksalen, BMC A10, Sölvegatan 17, Lund.
Opponent
- Andrew Jackson (Dr)