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A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon

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Author

Summary, in English

Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.

Publishing year

1995

Language

English

Pages

6-53

Publication/Series

FEBS Letters

Volume

374

Issue

1

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Medicinal Chemistry

Keywords

  • *Prostatic Secretory Proteins
  • *Multigene Family
  • Molecular Sequence Data
  • Male
  • Humans
  • Guinea Pigs
  • Gonadal Steroid Hormones/genetics
  • *Exons
  • Molecular
  • *Evolution
  • Dna
  • Conserved Sequence
  • Animals
  • Base Sequence
  • Proteins/*genetics
  • Rats
  • Research Support
  • Non-U.S. Gov't
  • *Semen
  • Seminal Plasma Proteins
  • Seminal Vesicle Secretory Proteins
  • Sequence Homology
  • Nucleic Acid

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1873-3468