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GPR40 is expressed in glucagon producing cells and affects glucagon secretion.

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Author

Summary, in English

The free fatty acid receptor, GPR40, has been coupled with insulin secretion via its expression in pancreatic beta-cells. However, the role of GPR40 in the release of glucagon has not been studied and previous attempts to identify the receptor in alpha-cells have been unfruitful. Using double-staining for glucagon and GPR40 expression, we demonstrate that the two are expressed in the same cells in the periphery of mouse islets. In-R1-G9 hamster glucagonoma cells respond dose-dependently to linoleic acid stimulation by elevated phosphatidyl inositol hydrolysis and glucagon release and the cells become increasingly responsive to fatty acid stimulation when overexpressing GPR40. Isolated mouse islets also secrete glucagon in response to linoleic acid, a response that was abolished by antisense treatment against GPR40. This study demonstrates that GPR40 is present and active in pancreatic alpha-cells and puts further emphasis on the importance of this nutrient sensing receptor in islet function. (c) 2006 Elsevier Inc. All rights reserved.

Department/s

Publishing year

2007

Language

English

Pages

240-245

Publication/Series

Biochemical and Biophysical Research Communications

Volume

354

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Keywords

  • pancreatic islets
  • diabetes
  • glucagon
  • alpha-cell
  • GPR40
  • free fatty acid

Status

Published

Research group

  • Drug Target Discovery
  • Immunology
  • Islet cell physiology

ISBN/ISSN/Other

  • ISSN: 1090-2104