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Common sequence variants on 20q11.22 confer melanoma susceptibility

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Author

  • Kevin M. Brown
  • Stuart MacGregor
  • Grant W. Montgomery
  • David W. Craig
  • Zhen Zhen Zhao
  • Kelly Iyadurai
  • Anjali K. Henders
  • Nils Homer
  • Megan J. Campbell
  • Mitchell Stark
  • Shane Thomas
  • Helen Schmid
  • Elizabeth A. Holland
  • Elizabeth M. Gillanders
  • David L. Duffy
  • Judith A. Maskiell
  • Jodie Jetann
  • Megan Ferguson
  • Dietrich A. Stephan
  • Anne E. Cust
  • David Whiteman
  • Adele Green
  • Håkan Olsson
  • Susana Puig
  • Paola Ghiorzo
  • Johan Hansson
  • Florence Demenais
  • Alisa M. Goldstein
  • Nelleke A. Gruis
  • David E. Elder
  • Julia Newton Bishop
  • Richard F. Kefford
  • Graham G. Giles
  • Bruce K. Armstrong
  • Joanne F. Aitken
  • John L. Hopper
  • Nicholas G. Martin
  • Jeffrey M. Trent
  • Graham J. Mann
  • Nicholas K. Hayward
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Summary, in English

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

Publishing year

2008

Language

English

Pages

838-840

Publication/Series

Nature Genetics

Volume

40

Issue

7

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1546-1718