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Biological monitoring of toluene diisocyanate (TDI) exposure by analysis of urine from exposed workers

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Author

  • Christian Lindh
  • Carl Johan Sennbro
  • Håkan Tinnerberg
  • Hans Welinder
  • Bo A Jönsson

Summary, in English

A gas chromatography-negative ion chemical ionization-selected ion monitoring-mass spectrometry (GC-NICI-SIM-MS) method was used to quantitate the metabolite toluene diamine (TDA) in urine samples of toluene diisocyanate (TDI) exposed workers. In order to validate the biological monitoring method, air samples were collected and analyzed using a liquid chromatography tandem mass spectrometry (LC-MS) method. The urine samples were treated with liquid-liquid extraction to retrieve the toluene diamine (TDA). It was observed that urinary TDA levels were applicable fro biological monitoring of TDI exposure.

Publishing year

2002

Language

English

Pages

655-656

Publication/Series

Proceedings 50th ASMS Conference on Mass Spectrmetry and Allied Topics

Document type

Conference paper

Publisher

American Society for Mass Spectrometry, Santa Fe, NM, 87505, United States

Topic

  • Environmental Health and Occupational Health

Keywords

  • Liquid-liquid extraction
  • Toluence diisocyanate (TDI)
  • Toluene diamine (TDA)
  • Time weighted average (TWA)

Conference name

Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Conference date

2002-06-02 - 2002-06-06

Conference place

Orlando, FL, United States

Status

Published