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Stem cell therapy for Parkinson's disease: where do we stand?

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Author

Summary, in English

A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.

Publishing year

2004

Language

English

Pages

261-273

Publication/Series

Cell and Tissue Research

Volume

318

Issue

1

Document type

Journal article review

Publisher

Springer

Topic

  • Cell Biology

Keywords

  • Parkinson's disease
  • Neural grafting
  • Embryonic stem cells
  • Somatic adult stem cells

Status

Published

Research group

  • Neural Plasticity and Repair

ISBN/ISSN/Other

  • ISSN: 1432-0878