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Cytogenetic aberrations in Ewing sarcoma: are secondary changes associated with clinical outcome?

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Author

Summary, in English

BACKGROUND: Ewing sarcoma is associated with a nonrandom pattern of primary and secondary chromosomal aberrations. Whereas the finding of rearrangements of chromosome 22, usually in the form of a balanced translocation t(11;22)(q24;q12), is important diagnostically, nothing is known about the potential prognostic impact of the secondary chromosomal aberrations. PROCEDURE: During a 1 3-year-period, short-term cultured tumor samples from 21 children and young adults with Ewing sarcoma were cytogenetically analyzed successfully. RESULTS: Clonal chromosome aberrations were detected in 18 patients, 17 of whom had the characteristic t(11;22)(q24;q12) or variants thereof. The most frequent secondary change was +8, followed by +12, +2, +5, +9, +15, and gain of material from the long and short arms of chromosome 1. The only recurrent secondary change that was restricted to tumors from the ten patients that were dead at latest follow-up was gain of 1q material. Furthermore, all three patients with tumors with chromosome numbers over 50 had died, and the only patient with a tumor karyotype lacking chromosome 22 rearrangement was alive without evidence of disease. CONCLUSIONS: These data and previously published results indicate that the karyotypic pattern not only may be of diagnostic significance but also may be important prognostically.

Publishing year

1999

Language

English

Pages

79-83

Publication/Series

Medical and Pediatric Oncology

Volume

32

Issue

2

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Pediatrics
  • Medical Genetics

Keywords

  • chromosome aberration
  • Ewing sarcoma
  • cytogenetics
  • clinical outcome

Status

Published

ISBN/ISSN/Other

  • ISSN: 1096-911X