New technologies to replace current blood typing reagents.
Author
Summary, in English
Purpose of review This review summarizes recent developments in blood grouping and compatibility testing in transfusion medicine. Recent findings Identification of the molecular characteristics of the major human blood groups has provided an opportunity to develop methods for blood group phenotyping using DNA-based technology. Various studies have demonstrated the feasibility of such an approach and have demonstrated the potential to change current procedures for identifying compatible blood, both in routine settings and in highly immunized patients, for whom compatible blood is difficult to obtain. In the obstetric setting, isolation of cell-free DNA from maternal plasma for fetal blood grouping provides a minimally invasive method for determining the risk for haemolytic disease in the newborn. Recombinant technology for synthesizing blood group proteins, although in its infancy, has the potential to change longstanding antibody identification procedures. Summary The molecular revolution occurring throughout medicine is broadly manifest in all areas of transfusion medicine and should contribute to transfusion safety.
Department/s
Publishing year
2007
Language
English
Pages
677-681
Publication/Series
Current Opinion in Hematology
Volume
14
Issue
6
Links
Document type
Journal article
Publisher
Lippincott Williams & Wilkins
Topic
- Hematology
Keywords
- microarray
- DNA analysis
- blood groups
Status
Published
ISBN/ISSN/Other
- ISSN: 1531-7048