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Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis.

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Author

Summary, in English

BACKGROUND: Allergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood. Toll-like receptor 9 (TLR9) is a receptor for unmethylated CpG dinucleotides found in bacterial and viral DNA. The present study was designed to examine the expression of TLR9 in the nasal mucosa and in leukocytes derived from different cellular compartments during symptomatic allergic rhinitis. METHODS: The study was based on 32 patients with seasonal allergic rhinitis and 18 healthy subjects, serving as controls. Nasal biopsies were obtained before and after allergen challenge. Bone marrow, peripheral blood and nasal lavage fluid were sampled outside and during pollen season. The expression of TLR9 in tissues and cells was analyzed using immunohistochemistry and flow cytometry, respectively. RESULTS: TLR9 was found in several cell types in the nasal mucosa and in different leukocyte subpopulations derived from bone marrow, peripheral blood and nasal lavage fluid. The leukocyte expression was generally higher in bone marrow than in peripheral blood, and not affected by symptomatic allergic rhinitis. CONCLUSION: The widespread expression of TLR9 in the nasal mucosa along with its rich representation in leukocytes in different compartments, demonstrate the possibility for cells involved in allergic airway inflammation to directly interact with bacterial and viral DNA.

Publishing year

2007

Language

English

Pages

17-17

Publication/Series

Respiratory Research

Volume

8

Issue

17

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Respiratory Medicine and Allergy

Keywords

  • Middle Aged
  • Male
  • Leukocytes: metabolism
  • Humans
  • Female
  • Bone Marrow: metabolism
  • Biological Markers: metabolism
  • Nasal Mucosa: metabolism
  • Rhinitis
  • Adult
  • Allergic
  • Adolescent
  • Seasonal: metabolism
  • Toll-Like Receptor 9: metabolism

Status

Published

Research group

  • Laryngoesophagology, Allergy and Life Quality
  • Airway Inflammation and Immunology
  • Clinical and Experimental Allergy Research
  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1465-9921