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Novel immunodeficiency data servers

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Author

Summary, in English

The Internet contains scientific information in increasing amounts. It is possible to obtain the latest information, and Web services can easily be maintained and updated. We have set up three Internet ser vices an immunodeficiencies. Immunodeficiency-related mutation information is available in immunodeficiency mutation databases (IDbases). Currently 14 registries are distributed, including information about Bloom syndrome (BLMbase), X-linked agammaglobulinemia (BTKbase), X-linked and autosomal recessive chronic granulomatous diseases (CYBBbase for X-linked CGD, CYBAbase for p22(phox) deficiency NCF1base for p47(phox) deficiency NCF2base for p67(phox) deficiency), CD3 gamma and CD3 epsilon deficiencies (CD3Gbase, CD3Ebase), X-linked hyper-IgM syndrome (CD40Lbase), T-B+ severe combined immunodeficiency (JAK3base), V(D)J recombination defects (RAG1base, RAG2base), X-linked lymphoproliferative syndrome (SH2D1Abase), and ZAP-70 deficiency (ZAP70base). Information on laboratories analysing the genetic defects is collected to IDdiagnostics registry Due to the rareness of immunodeficiencies there are very few laboratories performing genetic diagnostics. Such laboratories are Listed in IDdiagnostics and physicians can use the registry to find a suitable laboratory for their diagnostic needs. Immunodeficiency Resource (IDR) is a comprehensive integrated knowledge base for all the information on immunodeficiencies, including clinical, biochemical, genetic, structural and computational data and analyses. Air three services are available at http: //www.uta.fi/imt/bioinfo/.

Publishing year

2000

Language

English

Pages

177-185

Publication/Series

Immunological Reviews

Volume

178

Document type

Journal article review

Publisher

Wiley-Blackwell

Topic

  • Immunology in the medical area

Status

Published

ISBN/ISSN/Other

  • ISSN: 1600-065X