Atrial Conduction and P-wave Characteristics: From histology to electrophysiology

Summary, in English

P-wave morphology reflects the projection of the depolarization vector on the electrocardiogram (ECG)lead axes in three-dimentional space and reflects both right and left atrial activation. The main purpose of current thesis was to explore the internal logic between the atrial conduction properties, including intra- and inter- atrial conduction, and P-wave characteristics from the level of histology to electrophysiology.

The current thesis consists of four substudies entitled as: (1) P-wave characteristics and histological atrial abnormalities; (2) Effects of baseline P-wave duration and choice of atrial septal pacing site on shortening atrial activation time during pacing; (3) Diagnosis of atrial tachycardia originating from the lower right atrium: importance of P-wave morphology in the precordial leads V3-V6; and (4) Variability of P-wave morphology predicts the outcome of circumferential pulmonary vein isolation in patients with recurrent atrial fibrillation, respectively.

• Author: Yan Huo
• Department/s: Cardiology
• Publishing year: 2015
• Language: English
• Publication/Series: Lund University Faculty of Medicine Doctoral Dissertation Series
• Volume: 2015104
• Full text: - 6 MB; Download statistics
• Document type: Dissertation
• Publisher: Cardiology, Dept of Clinical Science, Lund, Lund University
• Topic: Cardiac and Cardiovascular Systems
• Keywords: Atrial fibrillation; Sinus rhythm; Histology; Electrophysiology; Human; P-wave Morphology; Variability of P-wave morphology; P-wave duration
• Status: Published
• Supervisor: Pyotr Platonov; Fredrik Holmqvist; Andreas Bollmann
• ISBN/ISSN/Other: ISSN: 1652-8220; ISBN: 978-91-7619-183-5
• Defence date: 16 October 2015
• Defence time: 09:00
• Defence place: Segerfalksalen, BMC A10, Sölvegatan 17, Lund
• Opponent: Nils Edvardsson