The Escherichia coli ftsK1 mutation attenuates the induction of sigma(s)-dependent genes upon transition to stationary phase
Author
Summary, in English
A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of the rpoS regulon in the ftsK mutant, as did a deletion in the recA gene. Thus, a mutation in the cell division gene,ftsY, uncouples the otherwise coordinated induction of sigma(S)-dependent genes and the universal stress response gene, uspA, during entry into stationary phase. (C) 2002 Federation of European Microbiological Societies, Published by Elsevier Science B.V. All rights reserved.
Department/s
Publishing year
2002
Language
English
Pages
19-23
Publication/Series
FEMS Microbiology Letters
Volume
206
Issue
1
Document type
Journal article
Publisher
Oxford University Press
Topic
- Biological Sciences
Status
Published
Research group
- Microbial Ecology
ISBN/ISSN/Other
- ISSN: 1574-6968