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Biological effects of aminoguanidine : an update

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Author

Summary, in English

Aminoguanidine (AMG) was prepared more than 100 years ago. During the last 10 years two important effects of AMG have been discovered which have made this molecule attract a lot of interest. Firstly, AMG inhibits, in vitro and in vivo, formation of highly reactive advanced glycosylation end products (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging. AMG ameliorates various complications to diabetes and prevents age related arterial stiffening and cardiac hypertrophy, effects probably dependent on inhibition of AGEs formation. Secondly, AMG inhibits NO synthase particularly the inducible NO synthase isoform making AMG an important pharmacological tool. The inducible NO synthase isoform is associated with production of large quantities of NO synthase in response to e. g. cytokines. When these effects of AMG were disclosed it had already been known for many years that AMG, in nM concentrations, inhibits diamine oxidase. This enzyme catalyzes degradation of biologically active diamines such as histamine and putrescine. Data obtained from studies using AMG should be interpreted with precaution since this substance interferes with several important regulatory systems. In this review these important targets for AMG are addressed.

Publishing year

1999-10

Language

English

Pages

15-509

Publication/Series

Inflammation Research

Volume

48

Issue

10

Document type

Journal article review

Publisher

Birkhäuser Verlag

Topic

  • Immunology in the medical area

Keywords

  • Adenosylmethionine Decarboxylase
  • Amine Oxidase (Copper-Containing)
  • Animals
  • Enzyme Inhibitors
  • Glycosylation End Products, Advanced
  • Guanidines
  • Humans
  • Nitric Oxide Synthase

Status

Published

Research group

  • Vascular Physiology

ISBN/ISSN/Other

  • ISSN: 1023-3830