Comparative immunohistochemical demonstration of difucosylated carbohydrate antigens and CEA in adenomas and carcinomas of the rectum and rectosigmoid
Author
Summary, in English
The present immunohistochemical investigation reveals that difucosylated carbohydrate antigens (DFCA) are extensively expressed in rectal and rectosigmoid carcinomas while normal mucosa and hyperplastic polyps are mainly negative. The adenomas showed intermediate staining patterns where adenomas with villous structures and moderate-severe dysplasia resembled of carcinomas. CEA was more extensively expressed in both normal, premalignant, and malignant tissue. Thus, DFCA is better than CEA as a discriminator between normal and malignant tissue in the distal large bowel, and may be used in future studies with the intention of advancing our understanding of the neoplastic process and assessing clinical relevance.
Department/s
Publishing year
1986
Language
English
Pages
139-146
Publication/Series
Anticancer research
Volume
6
Issue
2
Document type
Journal article
Publisher
International Institute of Cancer Research
Topic
- Cancer and Oncology
Status
Published
ISBN/ISSN/Other
- ISSN: 1791-7530