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Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia

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Author

Summary, in English

The development of neural transplantation as a treatment for Parkinson's disease has been compromised by a lack of functional efficacy and the appearance of transplant-induced motor side-effects in some patients. Since the first reports of these graft-induced dyskinesias (GID), and the realization of their impact on the progress of the field, a great deal of experimental work has been performed to determine the underlying cause(s) of this problematic side-effect. In this review we describe the clinical phenomenon of GID, explore the different representations of GID in rodent models, and examine the various hypotheses that have been postulated to be the cause. Based on the available clinical and preclinical data we outline strategies to avoid GID in future clinical trials using fetal cell transplants or cell preparations derived from stem cells.

Publishing year

2010

Language

English

Pages

295-309

Publication/Series

Progress in Brain Research

Volume

184

Document type

Journal article review

Publisher

Elsevier

Topic

  • Neurosciences

Keywords

  • Parkinson's disease
  • Transplantation
  • Dopamine
  • Dyskinesia
  • Graft-induced dyskinesia
  • L-dopa-induced dyskinesia
  • Amphetamine-induced dyskinesia

Status

Published

Research group

  • Neurobiology

ISBN/ISSN/Other

  • ISSN: 1875-7855