Novel supermacroporous dextran gels
Author
Summary, in English
Supermacroporous dextran gels (SDGs), having pores tens of micrometers in size and highly interconnected, were prepared from dextran macromonomer through radical polymerization at subzero temperatures and compared with dextran gels prepared at ambient temperature. Dextran macromonomer was synthesized via glycidyl methacrylate derivatization of dextran T500 in DMSO medium. The derivatization of dextran was confirmed by H-1-NMR and FT-IR spectroscopy. Scanning electron microscopy revealed macropores up to 100 mu m in size. SDGs can be dried and re-swollen within seconds retaining their porous structure. The large size of interconnected pores, fast swelling and biocompatibility of dextran make SDGs promising material for tissue engineering and cell culture.
Department/s
Publishing year
2006
Language
English
Pages
1075-1092
Publication/Series
Journal of Biomaterials Science. Polymer Edition
Volume
17
Issue
10
Document type
Journal article
Publisher
VSP BV
Topic
- Basic Medicine
Keywords
- cell
- interconnected pores
- swelling
- dextran
- supermacroporous gel
- scaffolds
Status
Published
Research group
- Insulin Signal Transduction
ISBN/ISSN/Other
- ISSN: 0920-5063