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Neural expression and increased lavage fluid levels of secretoneurin in seasonal allergic rhinitis.

På svenska

Author

  • Magnus Korsgren
  • Jonas S Erjefalt
  • Josef Hinterholzl
  • Reiner Fischer-Colbrie
  • Cecilia Ahlstrom Emanuelsson
  • Morgan Andersson
  • Carl Persson
  • Alan Mackay-Sim
  • Frank Sundler
  • Lennart Greiff

Summary, in English

Secretoneurin is a neuropeptide potentially involved in migration of eosinophils, monocytes, and dendritic cells. Whether secretoneurin is present in the human airway mucosa and whether it is released at ongoing allergic airway inflammation is currently unknown. In patients with allergic rhinitis, we have explored the occurrence of secretoneurin in nasal mucosal biopsies and lavage fluids before and during natural allergen exposure. Immunohistochemical analysis revealed an abundance of nerves displaying secretoneurin immunoreactivity, which were distributed predominantly around blood vessels and submucosal glands. A majority of nerve fibers containing vesicular acetylcholine transporter, tyrosine hydroxylase, calcitonin gene–related peptide, and vasoactive intestinal peptide were also secretoneurin-immunoreactive, indicating a localization of secretoneurin in cholinergic, adrenergic, and sensory nerves. Lavage fluid levels of secretoneurin were increased at allergen exposure (p < 0.01–0.05). Levels of secretoneurin did not correlate with eosinophil cationic protein ({rho} = 0.1, p = 0.7). We conclude that secretoneurin has a widespread occurrence in nasal mucosal nerves of patients with seasonal allergic rhinitis and that increased nasal lavage fluid levels of secretoneurin may characterize ongoing allergen exposure. These data favor a role of secretoneurin in the local traffic of immune cells in human airway mucosa.

Publishing year

2003

Language

English

Pages

1504-1508

Publication/Series

American Journal of Respiratory and Critical Care Medicine

Volume

167

Issue

11

Document type

Journal article

Publisher

American Thoracic Society

Topic

  • Respiratory Medicine and Allergy

Keywords

  • allergic airway inflammation
  • neuropeptides
  • eosinophils

Status

Published

ISBN/ISSN/Other

  • ISSN: 1535-4970