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Breast cancer incidence in ex-smokers in relation to body mass index, weight gain and blood lipid levels

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Author

  • Jonas Manjer
  • J Malina
  • Göran Berglund
  • Lennart Bondeson
  • J P Garne
  • Lars Janzon

Summary, in English

According to several studies breast cancer is more common among former smokers. This study explores whether this association has any relationship with anthropometric measurements or blood lipid levels. The 2082 ex-smokers (mean age 49.9 years) in the Malmo Preventive Cohort were followed for an average of 13.3 years using official cancer registries. This yielded 93 incident breast cancer cases. Oestrogen receptor (ER) status was assessed by an immunological method. Incidence of breast cancer covaried with height, body mass index, weight gain and cholesterol levels. None of these associations reached statistical significance. Incidence of breast cancer increased over quartiles of serum triglycerides, Ptrend: 0.02, relative risk (RR) for triglycerides as a continuous variable: 1.46 (1.21-1.77). Nineteen tumours were ER negative; this subgroup was similarly related to high triglycerides, 1.76 (1.40-2.21). All results were similar when BMI and cholesterol levels were entered into the model. It is concluded that breast cancer incidence covaries with triglyceride levels in ex-smokers.

Publishing year

2001

Language

English

Pages

281-287

Publication/Series

European Journal of Cancer Prevention

Volume

10

Issue

3

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cancer and Oncology

Keywords

  • Breast cancer
  • hormone receptor status
  • smoking cessation
  • triglycerides

Status

Published

Research group

  • Surgery
  • Internal Medicine - Epidemiology
  • Pathology, Malmö
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1473-5709