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Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system

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Author

Summary, in English

Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can lead to life-threatening complications. Here we report that activation of the contact system by Salmonella leads to massive infiltration of red blood cells and fibrin deposition in the lungs of infected rats. These pulmonary lesions were prevented when the infected animals were treated with H-D-Pro-Phe-Arg-chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease.

Publishing year

2000

Language

English

Pages

1415-1424

Publication/Series

Journal of Experimental Medicine

Volume

192

Issue

10

Document type

Journal article

Publisher

Rockefeller University Press

Topic

  • Cancer and Oncology
  • Infectious Medicine

Keywords

  • bradykinin
  • factor XII
  • high molecular weight kininogen
  • plasma kallikrein
  • protease inhibitor

Status

Published

ISBN/ISSN/Other

  • ISSN: 1540-9538