Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p.
Author
Summary, in English
Urothelial carcinoma shows frequent amplifications at 6p22 and 1q21-24. The main target gene at 6p22 is believed to be E2F3, frequently co-amplified with CDKAL1 and SOX4. There are however reports on 6p22 amplifications that do not include E2F3. Previous analyses have identified frequent aberrations occurring at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and genes.
Department/s
- Breastcancer-genetics
- Department of Translational Medicine
- Urothelial Cancer Genomics
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2013
Language
English
Publication/Series
PLoS ONE
Volume
8
Issue
6
Full text
Links
Document type
Journal article
Publisher
Public Library of Science (PLoS)
Topic
- Cancer and Oncology
Status
Published
Research group
- Urothelial Cancer Genomics
ISBN/ISSN/Other
- ISSN: 1932-6203