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WE-14, a chromogranin A - Derived neuropeptide

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Author

  • WJ Curry
  • SC Barkatullah
  • AN Johansson
  • JG Quinn
  • Per Norlén
  • CK Connolly
  • AP McCollum
  • CM McVicar

Summary, in English

The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-14 in the adrenal chromaffin cell population and in the enterochromaffin-like (ECL) cells of the oxyntic mucosa. Pathological analyses of neuroendocrine tumors have revealed a heterogeneous pattern of WE-14 immunostaining, with variable concentrations quantified and chromatographically resolved in tissue extracts. Phylogenetic surveys have demonstrated that WE-14 exhibits an ancient lineage, while ontogenetic examination has shown that it is generated at an early stage during fetal development. Putative WE-14 receptor binding sites have been identified in several tissues; however, the physiological role of WE-14 remains enigmatic.

Publishing year

2002

Language

English

Pages

311-316

Publication/Series

Annals of the New York Academy of Sciences

Volume

971

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Pharmacology and Toxicology
  • Medicinal Chemistry

Keywords

  • WE-14
  • chromogranin A

Status

Published

ISBN/ISSN/Other

  • ISSN: 0077-8923