Prednisolone in Bell's Palsy Related to Treatment Start and Age.
Author
Summary, in English
OBJECTIVE:: To evaluate if treatment start and age are related to the outcome in Bell's palsy patients treated with prednisolone. STUDY DESIGN:: Prospective, randomized, double-blind, placebo-controlled, multicenter trial. SETTING:: Sixteen otorhinolaryngologic centers in Sweden and 1 in Finland. PATIENTS:: Data were collected from the Scandinavian Bell's palsy study. A total of 829 patients were treated within 72 hours of onset of palsy. Follow-up was 12 months. INTERVENTION:: Patients were randomly assigned to treatment with placebo plus placebo (n = 206), prednisolone plus placebo (n = 210), valacyclovir plus placebo (n = 207), or prednisolone plus valacyclovir (n = 206). MAIN OUTCOME MEASURES:: Facial function was assessed with the Sunnybrook grading system, and complete recovery was defined as Sunnybrook = 100. Time from onset of palsy to treatment start was registered. RESULTS:: Patients treated with prednisolone within 24 hours and 25 to 48 hours had significantly higher complete recovery rates, 66% (103/156) and 76% (128/168), than patients given no prednisolone, 51% (77/152) and 58% (102/177) (p = 0.008 and p = 0.0003, respectively). For patients treated within 49 to 72 hours of palsy onset, there were no significant differences. Patients aged 40 years or older had significantly higher complete recovery rates if treated with prednisolone, whereas patients aged younger than 40 years did not differ with respect to prednisolone treatment. However, synkinesis was significantly less in patients younger than 40 years given prednisolone (p = 0.002). CONCLUSION:: Treatment with prednisolone within 48 hours of onset of palsy resulted in significantly higher complete recovery rates and less synkinesis compared with no prednisolone.
Department/s
Publishing year
2011
Language
English
Pages
141-146
Publication/Series
Otology & Neurotology
Volume
Dec
Links
Document type
Journal article
Publisher
Lippincott Williams & Wilkins
Topic
- Otorhinolaryngology
Status
Published
ISBN/ISSN/Other
- ISSN: 1537-4505