IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.

Summary, in English

CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation.

• Author: Emma Persson; Heli Uronen-Hansson; Monika Semmrich; Aymeric Rivollier; Karin Hägerbrand; Jan Marsal; Sigurdur Gudjonsson; Ulf Håkansson; Boris Reizis; Knut Kotarsky; William Agace
• Department/s: Mucosal Immunology; Adaptive Immunity; Medicine, Lund; Urology; Department of Clinical Sciences, Malmö
• Publishing year: 2013
• Language: English
• Pages: 958-969
• Publication/Series: Immunity
• Volume: 38
• Issue: 5
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23664832?dopt=Abstract; http://dx.doi.org/10.1016/j.immuni.2013.03.009
• Document type: Journal article
• Publisher: Cell Press
• Topic: Immunology in the medical area
• Status: Published
• Research group: Mucosal Immunology; Adaptive Immunity; Urology
• ISBN/ISSN/Other: ISSN: 1074-7613