The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Endothelin is a potent constrictor of human intracranial arteries and veins

På svenska

Author

  • Jan Erik Hardebo
  • J Kåhrström
  • Christer Owman
  • Leif Salford

Summary, in English

Endothelin, a peptide produced in endothelial cells, was found to be a potent constrictor of human pial arteries through a direct, slow action on the smooth muscle cell, with a pD2 value of 8.54. It was less potent as a constrictor in pial veins (pD2 7.80) and in branches of the middle meningeal artery and superficial temporal artery (pD2 7.61 and 7.77). The major component of the contractile response in the arteries comprises an effect on potential-operated calcium channels, as evidenced by tests with nimodipine. Endothelin may regulate intracranial vessels tonically during physiological as well as pathophysiological conditions.

Department/s

Publishing year

1989

Language

English

Pages

249-253

Publication/Series

Blood Vessels

Volume

26

Issue

5

Document type

Journal article

Publisher

Karger

Topic

  • Neurology

Status

Published

Research group

  • Drug Target Discovery

ISBN/ISSN/Other

  • ISSN: 0303-6847