Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.

Summary, in English

Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.

• Author: Anirban Bhattachariya; Diana Dahan; Mari Ekman; T Boettger; T Braun; Karl Swärd; Per Hellstrand; Sebastian Albinsson
• Department/s: Vascular Physiology; Cellular Biomechanics; Molecular Vascular Physiology
• Publishing year: 2015
• Language: English
• Pages: 133-143
• Publication/Series: Acta Physiologica
• Volume: 215
• Issue: 3
• Full text: - 727 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26052659?dopt=Abstract; http://dx.doi.org/10.1111/apha.12536
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Cell and Molecular Biology
• Status: Published
• Research group: Vascular Physiology; Cellular Biomechanics; Molecular Vascular Physiology
• ISBN/ISSN/Other: ISSN: 1748-1716