Osteopontin is increased in cystic fibrosis and can skew the functional balance between ELR-positive and ELR-negative CXC-chemokines.

Summary, in English

The glycoprotein osteopontin plays important roles in several states of disease associated with inflammation, for example by recruiting neutrophils but its expression and possible roles in cystic fibrosis (CF) have not been investigated.

• Author: Sandra Jovic; Medya Shikhagaie; Matthias Mörgelin; Jonas Erjefält; Sven Kjellström; Arne Egesten
• Department/s: Respiratory Medicine, Allergology, and Palliative Medicine; Airway Inflammation and Immunology; Infection Medicine (BMC)
• Publishing year: 2015
• Language: English
• Pages: 453-463
• Publication/Series: Journal of Cystic Fibrosis
• Volume: 14
• Issue: 4
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25492873?dopt=Abstract; http://dx.doi.org/10.1016/j.jcf.2014.11.010
• Document type: Journal article
• Publisher: Elsevier
• Topic: Immunology in the medical area; Respiratory Medicine and Allergy; Infectious Medicine
• Status: Published
• Research group: Airway Inflammation and Immunology
• ISBN/ISSN/Other: ISSN: 1873-5010