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Developing chicken oligodendrocytes express the type IV oligodendrocyte marker T4-O in situ, but not in vitro

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Author

Summary, in English

Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of myelination, and that the T4-O immunoreactive phenotype does not develop in vitro.

Publishing year

2000

Language

English

Pages

21-24

Publication/Series

Neuroscience Letters

Volume

284

Issue

1-2

Document type

Journal article

Publisher

Elsevier

Topic

  • Neurosciences

Keywords

  • Cell culture
  • T4-O
  • Myelination
  • Development
  • White matter
  • Spinal cord
  • Oligodendrocyte
  • Chicken

Status

Published

ISBN/ISSN/Other

  • ISSN: 0304-3940