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A Common Variant in the MTNR1B Gene Is Associated with Increased Risk of Impaired Fasting Glucose (IFG) in Youth with Obesity

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Author

  • Chao Zheng
  • Chiara Dalla Man
  • Claudio Cobelli
  • Leif Groop
  • Hongyu Zhao
  • Allen E. Bale
  • Melissa Shaw
  • Elvira Duran
  • Bridget Pierpont
  • Sonia Caprio
  • Nicola Santoro
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Summary, in English

Objective: To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the pathogenesis of impaired fasting glucose (IFG) in obese adolescents. Methods: A total of 346 Caucasians, 218 African-Americans, and 217 Hispanics obese children and adolescents underwent an oral glucose tolerance test (OGTT) and 518 underwent the evaluation of insulin secretion by the oral minimal model (OMM). Also, 274 subjects underwent a second OGTT after 3.0 -/+ 2.1years. Results: The MTNR1B rs10830963 variant was associated with higher fasting glucose levels and lower dynamic beta-cell response in Caucasians and Hispanics (P<0.05) and conferred an increased risk of showing IFG to Caucasians (P=0.05), African-Americans (P=0.0066), and Hispanics (P=0.024). Despite the association between the G6PC2 rs560887 and higher fasting glucose levels (P<0.05), there was no association between this variant and IFG at baseline or at follow-up (all P > 0.10). Conclusions: It has been shown for the first time in obese youth that the MTNR1B variant is associated with an increased risk of IFG.

Publishing year

2015

Language

English

Pages

1022-1029

Publication/Series

Obesity

Volume

23

Issue

5

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Endocrinology and Diabetes
  • Nutrition and Dietetics

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1930-739X