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Benchmark dose for cadmium-induced renal effects in humans

På svenska

Author

  • Yasushi Suwazono
  • Salomon Sand
  • Marie Vahter
  • Agneta Falk Filipsson
  • Staffan Skerfving
  • Jonas Lidfeldt
  • Agneta Akesson

Summary, in English

OBJECTIVES: Our goal in this study was to explore the use of a hybrid approach to calculate benchmark doses (BMDs) and their 95% lower confidence bounds (BMDLs) for renal effects of cadmium in a population with low environmental exposure. METHODS: Morning urine and blood samples were collected from 820 Swedish women 53-64 years of age. We measured urinary cadmium (U-Cd) and tubular effect markers [N-acetyl-beta-D-glucosaminidase (NAG) and human complex-forming protein (protein HQ in 790 women and estimated glomerular filtration rate (GFR; based on serum cystatin Q in 700 women. Age, body mass index, use of nonsteroidal anti-inflammatory drugs, and blood lead levels were used as covariates for estimated GFR. BMDs/BMDLs corresponding to an additional risk (benchmark response) of 5 or 10% were calculated (the background risk at zero exposure was set to 5%). The results were compared with the estimated critical concentrations obtained by applying logistic models used in previous studies on the present data. RESULTS: For both NAG and protein HC, the BMDs (BMDLs) of U-Cd were 0.5-1.1 (0.4-0.8) mu g/L (adjusted for specific gravity of 1.015 g/mL) and 0.6-1.1 (0.5-0.8) mu g/g creatinine. For estimated GFR, the BMDs (BMDLs) were 0.8-1.3 (0.5-0.9) mu g/L adjusted for specific gravity and 1.1-1.8 (0.7-1.2) mu g/g creatinine. CONCLUSION: The obtained benchmark doses of U-Cd were lower than the critical concentrations previously reported. The critical dose level for glomerular effects was only slightly higher than that for tubular effects. We suggest that the hybrid approach is more appropriate for estimation of the critical U-Cd concentration, because the choice of cutoff values in logistic models largely influenced the obtained critical U-Cd.

Publishing year

2006

Language

English

Pages

1072-1076

Publication/Series

Environmental Health Perspectives

Volume

114

Issue

7

Document type

Journal article

Publisher

National Institute of Environmental Health Sciences

Topic

  • Environmental Health and Occupational Health

Keywords

  • renal tubular dysfunction
  • glomerular dysfunction
  • renal
  • human
  • environmental exposure
  • benchmark dose
  • continuous data
  • urinary cadmium
  • risk assessment

Status

Published

Research group

  • Family Medicine and Community Medicine

ISBN/ISSN/Other

  • ISSN: 1552-9924