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Improved MALDI-TOF-MS analysis of partially depolymerised methyl cellulose by reducing end derivatisation

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Author

Summary, in English

The depolymerized methyl cellulose was analyzed, using improved MALDI-TOF-MS by reducing the end derivatization. The methyl cellulose was depolymerized to give methylated oligo-(1->4)-β-D-anhydroglucoses (M-oligo-AG). To reduce the errors during measurement of degree of substitution (DS), M-oligo-AG was derivatized with Girard's T reagent performed on an equimolar mixture of maltooligosaccharides. The GT-derivatized M-oligo-AG (GT-M-oligo-AG) formed singly charged molecular ions with peaks at m/z values 91 higher than the corresponding peaks of M-oligo-AG. The results show that for GT-M-oligo-AG the relative signal intensities for DP=1 and 2 were increased significantly.

Publishing year

2002

Language

English

Pages

421-422

Publication/Series

Proceedings 50th ASMS Conference on Mass Spectrmetry and Allied Topics

Document type

Conference paper

Publisher

American Society for Mass Spectrometry, Santa Fe, NM, 87505, United States

Topic

  • Analytical Chemistry

Keywords

  • Methyl cellulose
  • Matrix-assisted laser desorption/ionization (MALDI)
  • Time-of flight (TOF) mass spectrometry
  • Maltooligosaccharides

Conference name

Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Conference date

2002-06-02 - 2002-06-06

Conference place

Orlando, FL, United States

Status

Published