Thrombomodulin gene c.1418C>T polymorphism and risk of recurrent venous thromboembolism.

Summary, in English

Thrombomodulin gene (THBD) is a critical cofactor in protein C anticoagulant system. THBD c.1418C>T polymorphism is reported to be associated with higher risk of primary venous thromboembolism (VTE) but its role in VTE recurrence is unknown. The aim of this study was to investigate the role of THBD polymorphism in VTE recurrence. THBD c.1418C>T polymorphism was genotyped by using Taqman polymerase chain reaction in a prospective population based study of 1465 consecutive objectively verified VTE patients. Uni- and multivariate Cox regression were performed for the risk assessment of VTE recurrence. Patients who had VTE before inclusion or had recurrence or died during anticoagulant treatment were excluded. Among the remaining (N = 1046) patients, 126 (12.05 %) had VTE recurrence during the follow up period (from 1998 to 2008). THBD polymorphism was not significantly associated with risk of VTE recurrence in the univariate [Hazard ratio (HR) 1.11, 95 % confidence interval (CI) 0.78-1.59, p = 0.55] as well as the multivariate analysis adjusted for age, sex and thrombophilia (HR 1.11, 95 % CI 0.78-1.59, p = 0.54). Similarly, in unprovoked first VTE (n = 614), no association was observed between THBD polymorphism and risk of VTE recurrence (HR 1.22 and 95 % CI 0.78-1.89, p = 0.38). In this prospective study, our results do not suggest a predictive role for THBD c.1418C>T polymorphism in VTE recurrence.

• Author: Abrar Ahmad; Kristina Sundquist; Bengt Zöller; Peter Svensson; Jan Sundquist; Ashfaque Memon
• Department/s: Family Medicine and Clinical Epidemiology; Family Medicine, Cardiovascular Epidemiology and Lifestyle; Clinical Coagulation, Malmö; EpiHealth: Epidemiology for Health
• Publishing year: 2016-01-07
• Language: English
• Pages: 135-141
• Publication/Series: Journal of Thrombosis and Thrombolysis
• Volume: 42
• Issue: 1
• Full text: - 262 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26743062?dopt=Abstract; http://dx.doi.org/10.1007/s11239-015-1328-x
• Document type: Journal article
• Publisher: Springer
• Topic: Hematology
• Status: Published
• Project: Identification of diagnostic and prognostic biomarkers of venous thromboembolism and its recurrence; Genetic risk factor of venous thromboembolism and its recurrence
• Research group: Family Medicine and Clinical Epidemiology; Family Medicine, Cardiovascular Epidemiology and Lifestyle; Clinical Coagulation, Malmö
• ISBN/ISSN/Other: ISSN: 1573-742X