Anti-inflammatory properties of titanium in the joint environment. An experimental study in rats
Author
Summary, in English
Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative immunohistochemistry showed that normal joint synovial tissue is dominated by ED2-positive resident macrophages. Polyethylene implants induced a much stronger foreign-body reaction than titanium implants, as measured by the number of interfacial ED1-positive macrophages. The tissue response to titanium and polyethylene was also vastly different in arthritic synovial tissue compared with control tissue. It is likely that these biomaterials interact differently with inflammatory cells or intermediary compounds. It may be that arthritic synovial tissue produces reactive oxygen intermediates (free radicals) with which titanium has a unique anti-inflammatory interaction in vitro.
Department/s
- Neural Interfaces
- Department of Experimental Medical Science
Publishing year
1998
Language
English
Pages
888-893
Publication/Series
Journal of Bone and Joint Surgery: British Volume
Volume
80-B
Issue
5
Document type
Journal article
Publisher
British Editorial Society of Bone & Joint Surgery
Topic
- Neurosciences
- Medical Biotechnology
Status
Published
Research group
- Neural Interfaces
ISBN/ISSN/Other
- ISSN: 2044-5377