Effects of continuous Trichloroethylene inhalation on different strains of mice
Author
Summary, in English
Seven different strains of mice (wild, C57BL, DBA, B6CBA, A/sn, NZB and NMRI) were continuously exposed to 150 ppm trichloroethylene (TCE) during 30 days. After exposure all strains showed large increases in liver weight, while changes in kidney and spleen weights were small. Plasma butyrylcholinesterase (BuChE) activity increased in males of all strains and in females of strains A/sn and NZB. The increase in the females was less than that of the corresponding males. We concluded that there are moderate, but in some cases, significant differences in TCE sensitivity between different mouse strains. The differences observed between sexes emphasizes the importance of specifying sex as well as strain when reporting on toxic effects.
Publishing year
1983
Language
English
Pages
369-374
Publication/Series
Acta Pharmacologica et Toxicologica
Volume
53
Issue
5
Links
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Probability Theory and Statistics
Keywords
- liver
- trichloroethylene
- mice
- mouse strain
- spleen
- kidney
- esterase
- inhalation
- Body weight- butyrylcholin
Status
Published
ISBN/ISSN/Other
- ISSN: 0001-6683