Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington's Disease.

Summary, in English

In addition to classical neurological symptoms, Huntington's disease (HD) is complicated by peripheral pathology and both the mutant gene and the protein are found in cells and tissues throughout the body. Despite the adipose tissue gene expression alterations described in HD mouse models, adipose tissue and its gene expression signature have not been previously explored in human HD.

• Author: Andy McCourt; Jennifer Parker; Edina Silajdzic; Salman Haider; Huma Sethi; Sarah J Tabrizi; Thomas T Warner; Maria Björkqvist
• Department/s: Biomarkers in Brain Disease; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2015
• Language: English
• Pages: 371-382
• Publication/Series: Journal of Huntington's disease
• Volume: 4
• Issue: 4
• Full text: - 3 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26756592?dopt=Abstract; http://dx.doi.org/10.3233/JHD-150172
• Document type: Journal article
• Publisher: IOS Press
• Topic: Neurosciences
• Status: Published
• Research group: Biomarkers in Brain Disease
• ISBN/ISSN/Other: ISSN: 1879-6397