Integrative epigenomic analysis of differential DNA methylation in urothelial carcinoma.

Summary, in English

Urothelial carcinoma of the bladder (UC) is a common malignancy. Although extensive transcriptome analysis has provided insights into the gene expression patterns of this tumor type, the mechanistic underpinnings of differential methylation remain poorly understood. Multi-level genomic data may be used to profile the regulatory potential and landscape of differential methylation in cancer and gain understanding of the processes underlying epigenetic and phenotypic characteristics of tumors.

• Author: Mattias Aine; Gottfrid Sjödahl; Pontus Eriksson; Srinivas Veerla; David Lindgren; Markus Ringnér; Mattias Höglund
• Department/s: Urothelial Cancer Genomics; Breastcancer-genetics; Urological research, Malmö; Division of Translational Cancer Research; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2015
• Language: English
• Publication/Series: Genome Medicine
• Volume: 7
• Issue: 1
• Full text: - 4 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25810763?dopt=Abstract; http://dx.doi.org/10.1186/s13073-015-0144-4
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Cancer and Oncology
• Status: Published
• Research group: Urothelial Cancer Genomics; Urological research, Malmö
• ISBN/ISSN/Other: ISSN: 1756-994X